Dr. Sareh Parangi, MD

Specialty: Endocrine Surgery
Telephone: 617-852-0076

About Dr. Parangi

Dr. Parangi is a busy endocrine surgeon at Massachusetts General Hospital, Harvard Medical School in Boston, with a particular interest and expertise in thyroid and parathyroid tumors. She focuses her clinical efforts on endocrine surgery and applies her basic science knowledge and expertise to tumor progression in thyroid cancer. She performs over 300 endocrine surgery operations per year, many for thyroid cancer utilizing the latest technologies including recurrent laryngeal nerve monitoring. She has been in practice for 16 years. She has been a council member for the most prestigious organization of endocrine surgeons in the US, The American Association of Endocrine Surgeons, and a member of the American Thyroid Association. She has won numerous awards nationally and at Harvard Medical School for her research in the role of BRAF oncoprotein in thyroid cancer invasion. Her active research focuses on understanding why some patients with thyroid cancer do worse than others and how to help them.

She has been one of the Boston surgeons named in Best Doctor and her excellent in both research and her clinical expertise have earned her a national reputation. She is one of a handful of thyroid surgeons with expertise in molecular biology and has over 70 publications, many on thyroid cancer therapeutics in premier journal. She has taught about thyroid cancer care at the Harvard Course “Advances in Cancer Management for the Surgeon” and about thyroid and parathyroid ultrasound at the American College of Surgeons.

Her current practice includes:

• Surgery of the thyroid, parathyroid and adrenal glands, including use of intraoperative recurrent laryngeal nerve monitoring.

• Work up of thyroid nodules including thyroid ultrasound, thyroid fine needle aspiration and biopsy.

• Surgery on complex cases of aggressive thyroid cancers, recurrent thyroid cancer, and neck dissections. • Surgery on patients with parathyroid disease and familial parathryoid syndromes.

Click here to read Dr. Parangi’s CV.


Education and Training
Columbia University College of Physicians and Surgeons graduated 1990
Residency in General Surgery, University of California, San Francisco; 1998
Fellowship in Molecular Medicine , UCSF and Children’s Hospital Boston; 1995
Board Certification
American Board of Surgery 1998


Massachusetts General Hospital
15 Parkman Street
Wang 460
Boston, MA 02114

Selected Publications

Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies.
Clin. Chem.
Fitarelli-Kiehl, M.,Yu, F.,Ashtaputre, R.,Leong, K. W.,Ladas, I.,Supplee, J.,Paweletz, C.,Mitra, D.,Schoenfeld, J. D.,Parangi, S.,Makrigiorgos, G. M.

Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.
Cancer Cell
Gopal, R. K.,Kübler, K.,Calvo, S. E.,Polak, P.,Livitz, D.,Rosebrock, D.,Sadow, P. M.,Campbell, B.,Donovan, S. E.,Amin, S.,Gigliotti, B. J.,Grabarek, Z.,Hess, J. M.,Stewart, C.,Braunstein, L. Z.,Arndt, P. F.,Mordecai, S.,Shih, A. R.,Chaves, F.,Zhan, T.,Lubitz, C. C.,Kim, J.,Iafrate, A. J.,Wirth, L.,Parangi, S.,Leshchiner, I.,Daniels, G. H.,Mootha, V. K.,Dias-Santagata, D.,Getz, G.,McFadden, D. G.

Leadership in American Surgery: Women are Rising to the Top.
Ann. Surg.
Pories, S. E.,Turner, P. L.,Greenberg, C. C.,Babu, M. A.,Parangi, S.

Journal Article

Genome-Wide Analysis of Differentially Expressed miRNA in PLX4720-resistant and Parental Human Thyroid Cancer Cell Lines
Varmeh S, Vanden Borre P, Gunda V, Brauner V, Holm, T, Tammy Holm, Wang Y, Sadreyev R, and Parangi S

Detection of circulating BRAFV600E in patients with papillary thyroid carcinoma
Journal of Molecular Diagnostics
Lubitz CC, Parangi S, Holm TM, Bernasconi MJ, AP, Suh, H, Economopoulos KP, Gunda V, Donovan SE, Sadow PM, Wirth LJ, Sullivan RJ and Panka DJ

The truth about double adenomas: Incidence, Localization and intrapoerative PTH
Journal of the American College of Surgeons
De Gregorio L, Lubitz CC, Hodin RA, Gaz RD, Parangi S, Phitayakorn R and Stephen AE


Current tips for surgeon performed ultrasound for parathyroid disease
Brisbane, Australia

Molecular Testing in thyroid cancer
Brisbane, Australia

Vocal Cord Ultrasound, Is it Ready for prime time?
Brisbane, Australia


Measurement and Variation in Estimation of Quality of Life Effects of Patients Undergoing Treatment for Papillary Thyroid Carcinoma.
American Association of Endocrine Surgeons
De Gregorio, L, Fingeret AL, Economopoulos KP, Parangi S, Stephen AE, Halpern EF, Donelan K, Swan JS, and Lubitz C
Baltimore, MD

Accurate “Prediction of Nodal Status in Preoperative Patients with thyroid carcinoma using Next-Gen Nanoparticle
Radiological Society of North America
Kilcoyne A, Phitayakorn R, Daniels G, Parangi, S, Sadow P, Randolph G, and Harisinghani, M G Daniels; S Parangi; P Sadow; G Randolph
Chicago, IL

Hobnail variant, a new aggressive subtype of papillary thyroid cancer.
World Thyroid Congress
Lubitz C Parangi S, Faquin B and Sadow PM
Toronto, Canada

Book Chapter

Surgical Endocrinopathies: Clinical Management and the Founding Figures
Parangi S

Surgery of the Thyroid and Parathyroid Glands
Perrier ND and Parangi S

Clark: Textbook of Endocrine Surgery
McKenzie, T and Parangi, S


Doctor, what do you mean you can’t tell whether I have thyroid cancer?
Parangi S

Patient Videos with Review of thyroid nodule care
Parangi S

MGH Endocrine on thyroid nodules, thyroid biopsies and thyroid cancer treatment
Parangi S